MicroRNA-98 regulates foam cell formation and lipid accumulation through repression of LOX-1

MicroRNA-98 regulates foam cell formation and lipid accumulation through repression of LOX-1

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bilstein shocks jeep xj Objective: Several miR/s that regulate gene/s relevant in atherogenesis are being described.We identified a miR (miR-98) that targets LOX-1, a receptor for ox-LDL, and speculated that it might be relevant in atherogenesis.Approach and results: MicroRNA-98 was predicted by bioinformatics tools.The effects of miR-98 (by use of mimics and inhibitors) on LOX-1 expression and foam cell formation in mouse peritoneal macrophages were assessed.

ApoE-/- mice fed by high fat diet were administered with mmu-agomiR-98 and mmu-antagomiR-98, and expression of LOX-1 and foam cell formation in aorta were quantified.LOX-1 was established to valhalla axys be a direct target of miR-98 by luciferase reporter assay.Enhancement of miR-98 decreased the expression of LOX-1 and inhibited foam cell formation and lipid accumulation.Inhibition of miR-98 had the opposite effects on all parameters.

Conclusions: Reduced expression of miR-98 may relate to LOX-1 expression and foam cell formation and lipid accumulation in aortas of ApoE-/- mice.Plasma level of miR-98 may be a biomarker of atherosclerotic disease process and its modulation may offer a therapeutic strategy for atherosclerosis.Keywords: MiR-98, LOX-1, Ox-LDL, Foam cells.